The Mariners fell to 22-17, but of more immediate concern was Cano, their ironman-like second baseman who has played more games in the major leagues since his debut with the Yankees in 2005 than any other player.
John Hicks and Pete Kozma each had two RBI to lead the Tigers in the second game.
The Mariners have not yet announced a timetable for Cano's recovery, though a fracture bone in the hand will likely cost him several weeks.
Shane Greene pitched a 1-2-3 top of the ninth inning to earn the win.
The Tigers have been an average offensive team so far as they come in ranked 15th in the league in scoring, putting up 4.42 rpg, while also ranking 8th in hitting at.259 and 29th in homers with 31.More news: 19 dead in fighting between Myanmar army, rebels
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Dee Gordon grounded out to first to end it.
Gardenhire was dismissed in the bottom of the fifth inning by plate umpire Carlos Torres on Saturday night. The next hitter, Jean Segura, blasted a bases-loaded single up the middle past a diving Iglesias.
Suzuki shifted into a front office role earlier this month, but he didn't completely rule out playing again.
Cano is batting.287 with four home runs and 23 RBIs this season for Seattle. Both players are on the DL because of hamstring strains.
The Tigers are planning to start lefty Matthew Boyd (1-3, 3.00 ERA), who has 26 strikeouts and nine walks to his name, as well as a WHIP of 1.06.
Seattle heads to Minnesota for one makeup game Monday.