After a recent series of hospitalizations and consulting with her family doctors, the 92-year-old Bush family matriarch will no longer seek medical treatment, a family spokesman says.
Bush has been in and out of hospital recently and is now in "failing health", according to a family spokesman.
It said that Mrs Bush, after consulting with relatives and doctors, had made a decision to "focus on comfort care" at the family home in Houston.
"She is surrounded by a family she adores, and appreciates the many kind messages and especially the prayers she is receiving", the statement continued.
Here are some things to know about her: LITERACY EFFORTS The Barbara Bush Foundation for Family Literacy began during her White House years, with a goal to improve the lives of disadvantaged Americans by boosting literacy among parents and their children.
Husband George, the nation's 41st president, is now 93 years old and struggling with a Parkinson's-like disease that forces him to use a wheelchair and makes it hard for him to speak.More news: Carrie Underwood Posts First Close-Up Selfie Since Her Accident
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She is also known for her sense of humor, once joking that her husband couldn't keep a job, but that, at least, he wasn't boring. She was also diagnosed with Graves' disease in the 1980s.
Just this month, the former first lady wrote about her husband in a note for the spring edition of Smith College's alumnae magazine.
She continued: "Also, George Bush has given me the world". She married at age 19 while George Bush was a young naval aviator.
Barbara Pierce Bush was born in Rye, New York.
They traveled to Texas where the oil business dominated, first in Midland-Odessa, later to the Houston area where George found his love for politics.
Smith College awarded Barbara Bush with an honorary degree in 1989.