Victory over in-form Tottenham at Wembley and a United loss to bottom club West Bromwich Albion on Sunday would allow Pep Guardiola's side to start celebrating.
"It can happen", he told a news conference.
"So hopefully he'll be ready for the last games if we need him and for his World Cup".
"Since November and December we have already been champions, when I saw pundits and people say: 'Impossible for City to drop points'".
City are in the midst of a really concerning run of form, having lost their last three games, and Guardiola will be keen for his side to bounce back immediately with a win against Spurs tomorrow.
'What I say to the players is, and they show you every day, in every game that it's not done because if it was done they wouldn't play the way they play. So if we lose, we're going to do it in a similar way to the way we played against United and Liverpool. We need five points from six games and our first chance is [Saturday] in one of the toughest games.More news: Trump Promises To Leave Marijuana To The States
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"I think that was when he should have rested players and gone "right, we've got a big game, we'll win the league, whether it's the middle of April or the end of April, we're winning the league".
City were two up in the Manchester derby before Paul Pogba inspired a United comeback, scoring twice in the second half of their 3-2 win.
"Of course it can happen, I assure you".
During the defeat the two defeats to Liverpool, City were on the wrong end of three incorrect offside decisions that would have been overturned by VAR but clubs have voted against it being introduced.