As Merseyside derby build-ups go, this one has been particularly low-key. But, the form of Wayne Rooney and Theo Walcott is a major concern, and Liverpool should have enough firepower to edge their rivals on Saturday.
In all competitions Liverpool are unbeaten in 16 games against Everton (W8, D8) - their longest ever run without defeat against their Merseyside neighbours.
Everton head into this weekend's bout off the back of a 3-1 humbling by Premier League leaders City, with Yannick Bolasie's second half consolation providing the briefest bit of cheer on an unforgettable night. The Reds hadn't lost in their previous seven games, but certainly come into this clash on a high ahead of visiting City for the second leg next week.
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"I think it's an advantage we could possibly take". So the derby is the most important game for a lot of people. But Jürgen has a very strong squad and they haven't let him down all season. The derby has also been hugely one-sided in recent times, with Everton winning just one of the last 22 league meetings between the sides. They have a good home record. Here are the viewing details to see if they can overcome the Reds, some team news ahead of the match and a preview of what's to come in the first fixture of Week 33.
Eliaquim Mangala and Gylfi Sigurdsson won't be featuring for Everton. Each Evertonian thinks at Goodison they have an extra percentage of desire.
Sitting 26 points behind their neighbours in the league, and devoid of much inspiration since Sam Allardyce's appointment, they look unlikely to change that here. "I will not guarantee it but it doesn't look too bad he could start tomorrow", said the Reds boss. "We need to be ready for that 100%".
Nonetheless, Liverpool's front-trio of Mohamed Salah, Roberto Firmino and Sadio Mane have scored a total of 52 league goals between the three of them.
Klopp's side are in the midst of an injury crisis at the heart of their defence, with injuries to Joe Gomez and Joel Matip, they are lacking in experience and strength in depth.