But the clash is sandwiched between two games of even greater magnitude in the context of their season - a trip to Anfield on Wednesday and the second leg next week.
But this would not be pragmatic.
Sergio Aguero missed the win over Everton as he recovers from a knee injury and Guardiola says it's too early to say whether he will be fit enough to face Liverpool. We should finish the game with 11 first of all, that would be cool.
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Roberto Firmino, Sadio Mane and Mohamed Salah scored three goals in nine minutes that afternoon, and Guardiola acknowledges just how hard it will be to return from Merseyside with a positive result.
The Champions League tie will see thoughts of the title party put on hold for a few days, but next weekend's derby presents a potential dream scenario for fans.
Obviously, not conceding goals is desirable but it was City's lack of composure which was most startling as their technique and passing ability deserted them amid the type of roller-coaster atmosphere which Liverpool are capable of creating and which City have rarely faced this season.
McMahon's two former clubs are set to do battle for a place in the last four of the Champions League and contest the first leg of their quarter-final tie at Anfield this week. They are fantastic, fantastic players. It won't matter if City fail to stop Alexis Sanchez and Romelu Lukaku next Saturday, but it will mean everything if they can stifle Salah, Mane and Firmino. I don't think it gives us a big advantage against them, but no problem with that.
"But now that we've got them, Liverpool for me have to be able to do what they did against City at Anfield twice".
"The other team is Sevilla, since we already played there".