United, three time winners of this competition, drew 0-0 in the first leg in Spain last month.
Jose Mourinho turned to Pogba to influence the game at a crucial stage but the France worldwide was arguably United's worst performer and he gave the ball away a number of times in good areas.
The verdict is that both teams to score (GG) and Manchester United to win (2-1).
Joining Manchester United in 2006 from Spurs, the midfielder has won five Premier League titles and a Champions League amongst various other honours at Old Trafford.
United finally worked a clear opening in the 38th minute, a powerful drive from Marouane Fellaini beaten away by Sergio Rico after Alexis Sanchez turned a one-two into the path of the Belgium worldwide, who was making his first start of 2018.More news: Intel may be considering a takeover of Broadcom
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"We'll be playing 100 per cent to try and achieve that". The United manager attempted to retrieve the situation by throwing on Anthony Martial and Mata, but it was too little, too late.
It was United who started on the front foot, with Lukaku seeing two early chances go begging following some good link up play with Lingard.
What needs to change to bring the team up to the desired Champions League level? The Belgian flashed the first over from 20 yards after a good one-two with the winger, before Sevilla defender Langlet did well to block his second attempt on the edge of the six yard box following a risky ball in from Lingard. And after replacing the ineffective Muriel, he scored two goals with his first two touches at Old Trafford.
Bailly's superbly-timed challenge denied Correa in the box, then Rico had to make a smart save down to his right to turn a snapshot from Jesse Lingard around the post. "We are not the only team that invests money in players".
Before United could respond it was 2-0 and game over, chaotic defending allowing Ben Yedder to divert a goalbound header that a desperate De Gea was unable to stop crossing the line.
"We deserved this. We were patient, we knew that one goal could see us reach the quarter-finals".