Liverpool will be hoping to consolidate their place in the top four when they travel to Southampton on Sunday.
During his pre-match press conference at Melwood on Friday, Klopp was asked about the reception he expects the Dutchman to receive from the home crowd.
Liverpool were forced to abandon their pursuit of the Dutch global last summer and publicly apologised for an alleged illegal approach.
In anticipation of a first meeting with Mauricio Pellegrino's side, Klopp revealed he plans discuss the potential powder keg atmosphere with the 26-year-old.
"It is not the most lucky season and of course there is a kind of frustration in him", said the Reds boss. But we are all human beings, we are influenced by circumstances. It won't be a normal game.More news: AAA study finds drowsy-driving crashes more prevalent than thought
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"How football fans are, they want to disturb what we do". It's not nice, I spoke to him, it's now how it should be. But it's not something we really think about. We really think much more about the football game and what we have to do and not about how we can avoid different situations from outside because we don't have influence.
"There are a few good players from there so maybe we should have a scouting department at Southampton", Klopp joked.
Le Tissier said: "I think if Liverpool have realistic ambitions of the title then I think they need a better centre-back partner and goalkeeper". We have to accept it how it is: loud, not nice maybe, but still we have to play football.
While no official bid was submitted after Southampton's anger at leaked reports suggesting a deal was all but done, the Merseyside club had made it clear their willingness to spend £60 million-plus to sign the player. He did well in our club and he left some profit to the club and we have to grateful.
Klopp also complimented the Southampton club for the work they do in nurturing players who have since gone on to join Liverpool.