New Zealand at home is a formidable proposition in any case, and given the dominance, it has established in the Windies' tour so far, it will take something special from the visiting side to topple the home team and keep the ODI series alive.
But from there, Henry Nicholls and Todd Astle flattened them with a sixth-wicket stand of 130 runs in 98 balls.
Trent Boult's career-best 7 for 34 set the record for the best ODI returns by a New Zealand bowler against West Indies.
He removed Munro (30) and Neil Broom (six) in quick succession before Worker and Ross Taylor steadied the innings with a 58-run partnership at better than a run-a-ball pace.
After he finished off the top order, Lochie Ferguson plucked out the middle with three wickets in 10 deliveries, including Jason Mohammed and Rovman Powell with consecutive balls. Ashley Nurse (27) did play a hand down the order but by that time it was nearly over for the Caribbeans.
George Worker and Ross Taylor also chimed in with half- centuries to propel New Zealand into solid position.
The West Indian fast bowlers made good use of the short ball throughout most of the innings, and looked to be in control after reducing New Zealand to 186-5 with 17 overs to go before Nicholls went on a late surge.
Nicholls' unbeaten 83 off 62 balls led the way to his best-ever ODI tally, the 26-year-old left-hander belting seven fours and two sixes along the way.More news: Hardik Patel meets Praveen Togadia, deplores attempts to silence VHP leader
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Even without Southee, a line-up of Trent Boult, Lockie Ferguson, Matt Henry and Doug Bracewell - the first ODI hero - can cause plenty of problems to the batsmen.
"We didn't play good cricket", he said. We bowled reasonably well but let ourselves down in the last ten overs.
Ashley Nurse (27) provided some resistance but the Windies were comprehensively beaten heading into the third and final ODI on Boxing Day.
"It's nice any time you get runs and it's nice to contribute not just to the team total, but a team win", he said.
"There was a little bit of movement early on, but I didn't expect seven wickets", said Boult.
"I'm still not able to give a strong position on where he's at but he is better than the last game".
"We were trying to get 300 in 25 overs, when we had 50 overs to get it".
Stand-in skipper Tom Latham paid tribute to Nicholls and Astle, as well as Boult.