Co-written and co-produced by Timberlake, Timbaland, and Danja, with additional writing from James Fauntleroy and Larrance Dopson, the dance-ready track finds J.T. experimenting with a new futuristic sound.
The song will be featured on the 36-year-old singer's upcoming album Man of the Woods, which will be released on February 2.
Mark Romanek directed the video.
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Earlier this week, he released a teaser for the record, which saw Justin roaming around in the woods, whilst wife Jessica Biel provided a deep, serious and thought-provoking voiceover in which she says: "It feels like mountains, trees, campfires, like Wild West but now".
Get "Filthy" with J.T. below.
He worked with his frequent collaborators Timbaland and Pharrell (via The Neptunes) on the album, in addition to Alicia Keys and Chris Stapleton.
Justin Timberlake will drop three more videos created by three different directors before the release of Man of the Woods, which is set to drop on 2 February, just two days before he takes to the stage in Minneapolis for the Super Bowl halftime show on Sunday, 4 February.