Cleveland rookie quarterback DeShone Kizer passed for 232 yards and a touchdown and also carried seven times for 57 yards.
The game was tied 24-24 entering the fourth quarter. The Browns have not won a game all season and if the Lions were to lose, it would be devastating to their playoff chances. Golden Tate caught six passes for 97 yards and a score, while cornerback Nevin Lawson returned a fumble 44 yards for a touchdown. Running back Ameer Abdullah rushed for 52 yards and a score on just 11 carries. Isaiah Crowell and Duke Johnson ran well.
Run Defense - The Browns normally stout run defense got gashed by runs of 20, 10 and 21 yards on consecutive plays - with Garrett, Ogbah and Shelton on the sideline - on 1 drive that eventually ended in a Matt Prater 46-yard field goal with 6:00 left in the 1st quarter to cut Cleveland's lead to 10-3.
Emmanuel Ogbah had four sacks, and Christian Kirksey and Joe Schobert each added a sack.More news: 'I would NEVER' call Rocket Man Kim Jong Un 'short and fat'
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This interception by Cleveland outside linebacker Jamie Collins was only his first of the year and sixth of his career.
Myles Garrett continues to make things happen when he is on the field.
Finding the formula: It took a while but the Browns finally found their running game - and they used it. Cleveland ran for 201 yards in the loss, 118 in the second half.
Even players who have been protesting most of the season stood for the anthem this week, including the Seahawks Michael Bennett, who stood before Thursday night's game.
Kizer was having his best game of the season before suffering a rib injury that forced him to the locker room.