Loftus-Cheek was named Man of the Match for his performance from an attacking midfield position, growing into the role to produce an accomplished creative display.
In a much-changed first-11 Southgate has handed debuts to three players: Jordan Pickford, Ruben Loftus-Cheek, and Tammy Abraham.
The 21-year-old grew into the match as time went on and was involved in some neat moves for the hosts, who also handed debuts to goalkeeper Jordan Pickford, forward Tammy Abraham and defender Joe Gomez, who came on as a first-half substitute for the injured Phil Jones.
And he sparkled against the world champions on his worldwide bow by putting in a display that earned him the man-of-the match award.
Against a well-oiled machine, they will have periods in the game where they control possession but I didn't think they hurt us. "It was a really tactical game". For me, I would never want to rewind the time, because I learned a lot about myself mentally and I feel like I got mentally stronger. There are still loads of things we can get better at the more we play that system. "I was with him for almost three years in the Under-21s, so it wasn't too much of a new thing coming here", a visibly exhilarated Loftus-Cheek stated.
"I'm really not surprised with what they've done because they've shown that previously in younger ages and in the week in training, there's been an energy about the group".More news: Hope Solo accuses Sepp Blatter of sexual assault at awards ceremony
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Now the Lewisham-born star hopes an impressive campaign for Palace will earn him a spot in the squad for next year's world showpiece.
"To go to the World Cup?". He has the physical attributes and can handle the ball.
He said: "Loftus-Cheek is a player I've watched do that since U16 level, and despite his size and appearance and the way he plays, he's not hugely confident at times".
"It took him 10 minutes to realise he's OK here", the England boss told the BBC.
I see things in him that lead me to believe he can play at this level. He's one that for the wider public may have flown under the radar a bit until now.