The drills, rare due to the complexity of the ships' action coordination, will last until November 14.
This is the first time that three carrier strike groups have operated together in the Western Pacific since exercises Valiant Shield 2006 and 2007 off the coast of Guam.
The U.S. 7th Fleet on Wednesday said three aircraft strike groups would begin a "three-carrier strike force exercise in the Western Pacific" from Saturday to Tuesday.
During the drill, the first of its kind in a decade, the warships will carry out air strike and defense simulations, maritime surveillance, sea supply, coordinated fenced maneuvers and other training, added the Navy.
'Unprecedented show of force' aims to warn North Korea against launching any attack on the USA or its allies.
From the South Korean side, two Aegis-equipped destroyers, one destroyer and four frigates will be mobilized for the joint exercises with the US carriers, according to Yonhap.
"Multiple carrier strike force operations are very complex, and this exercise in the Western Pacific is a strong testament to the U.S. Pacific Fleet's unique ability and ironclad commitment to the continued security and stability of the region".More news: Alibaba's Singles' Day is retail gold
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The Ministry of National Defense (MND) on Thursday confirmed to media that this will be the first time that the ROK and the US navies stage joint bilateral drills with the three aircraft carriers in waters off the east coast of the country.
Pyongyang detonated its sixth and most powerful nuclear bomb in September after months of ballistic missile tests that riled Washington and its allies Japan and South Korea.
During his recent visit to Seoul, Trump said, " North Korea is not the paradise your grandfather envisioned.
Trump launched a stinging attack on North Korea leader Kim Jong-un during the trip, branding him a "deranged tyrant", whose country is a "hell that no person deserves".
-South Korean alliance, and that diplomacy was most effective "when backed by credible military force".
He said of the North Korean threats to strike the USA and its allies, "That would be a fatal miscalculation".
Still, he warned Pyongyang that its military was no match for the U.S.