Uganda can qualify for the World Cup in Russian Federation if they beat Ghana and Congo Brazzaville and hope that Egypt falters in one of their games.
The coach has been forced to bring in five new players to the squad, all set to earn their first caps.
The Black Stars have pitched camp in Kenya and trained at Kasarani Stadium on Wednesday ahead of the penultimate 2018 Fifa World Cup qualifier set for Namboole Stadium on Saturday.
Egypt because they are playing away against Ghana in the last game.
Captain Asamoah Gyan was withdrawn from the squad due to injury and his deputy Andre Ayew was not called up.More news: 16 people killed after train collides with bus
More news: 'You think I care?' Hart dismisses critics after World Cup qualification
More news: India's role in US's Afghan policy unacceptable, Asif tells Tillerson
Egypt will officially qualify if they beat Congo in Alexandria and Uganda stumble against Ghana in the same round.
"Players that are in now, their confidence levels are rising slowly and for that reason I believe when they go out there, there's not too much pressure on them", Appiah said, adding the players will be looking to "express themselves" on the pitch.
The former Uganda Cranes skipper was named as part of the interim technical staff for the national team since Mulitin "Micho" Sredojevic left and was available for the back to back games against Egypt.
Meanwhile, Coach Kwasi Appiah and his players have intensified their preparation for Saturday's clash at their training basse in the Kenbyan capital, Nairobi.
"We were hoping to get the full house but unfortunately Thomas Agyepong, Harrison, Jonathan Mensah, Asamoah Gyan and Afriyie Aquah are all out".