This press briefing is scheduled to begin at 2:00 p.m.
The Trump administration is expected to name former Trump transition team official Anthony Scaramucci as White House communications director, four sources in and close to the White House told NBC News Thursday.
Sanders read a statement from Trump at the briefing, saying he was "grateful" for Spicer's White House service and that he wished him well. Since then, White House press secretary Sean Spicer has assumed the bulk of the position's responsibilities in the interim.
Trump picked Wall Street financier Anthony Scaramucci, a long-time supporter, to be his White House communications director on Friday, White House official Sarah Sanders said earlier. Sanders has instead frequently taken the podium at the White House briefings, which have often been held off camera.
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After Spicer's resignation, Priebus said he supports Scaramucci "100 percent", according to news reports. That became a sticking point with several members of the White House press corps, who expressed concern that the White House was attempting to stonewall the press and their access to the information they rely on to try and report on the President.
"I have questions still about the White House's ability to manage communications issues". The two worked at the Republican National Committee before joining the administration.
Oscar-nominated actress Melissa McCarthy performed memorable parodies of Mr Spicer's press briefings, immediately going viral with her boisterous comic performance.
The new press secretary is the daughter of former Arkansas governor and two-time presidential candidate Mike Huckabee and grew up with a fascination for politics.
Fox News Channel's Sean Hannity might be the ringmaster of a three-ring circus in a few hours.
Mr Spicer said it was "the largest audience ever to witness an inauguration, period". But the shakeup comes amid intensifying tumult at the White House as Trump moves to respond to the widening special counsel probe into his campaign's possible collusion with the Russian government and searches for ways to revive the administration's stalled legislative agenda.